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Related Experiment Videos

Multiple sclerosis: search for a serologic inhibitor

B Ryberg

    Acta Neurologica Scandinavica
    |September 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    Complement-fixing (CF) antibrain antibodies are common in multiple sclerosis (MS). This study found no evidence of inhibiting factors in MS serum or CSF, suggesting negative results are likely due to antibody absence.

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    Area of Science:

    • Neuroimmunology
    • Clinical Immunology
    • Serology

    Background:

    • Complement-fixing (CF) antibrain antibodies are frequently detected in the serum and cerebrospinal fluid (CSF) of patients with multiple sclerosis (MS).
    • A negative result in CF antibody testing may arise not only from a lack of antibodies but also from the presence of serologic inhibiting factors.

    Purpose of the Study:

    • To investigate the potential presence of serologic inhibiting factors in the serum and CSF of multiple sclerosis patients that could interfere with complement fixation tests for antibrain antibodies.

    Main Methods:

    • Serum and concentrated CSF samples from multiple sclerosis patients, which were negative for demonstrable CF antibrain antibodies, were tested.
    • These samples were incubated with standardized positive complement fixation reactions for both antibrain antibodies and a Wasserman reaction to detect inhibiting activity.

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    Main Results:

    • No evidence of inhibiting activity was detected in 11 CSF samples and 15 serum samples from 20 multiple sclerosis patients.
    • In contrast, inhibiting activity was observed in the serum of 4 out of 12 patients with neoplasms and 3 out of 11 patients with rheumatoid arthritis.

    Conclusions:

    • The study did not find evidence of inhibiting factors in the serum or CSF of multiple sclerosis patients that would interfere with complement fixation tests for antibrain antibodies.
    • The findings suggest that negative results in these tests for MS are more likely attributable to the absence of antibodies rather than the presence of inhibitors.