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Doxepin-induced acute glossitis

T J Ives, R B Stewart

    American Journal of Hospital Pharmacy
    |November 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    Doxepin medication can cause acute glossitis, a painful tongue inflammation. This condition resolved upon drug discontinuation and recurred when the medication was restarted, highlighting its causal link.

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    Area of Science:

    • Oral medicine
    • Pharmacology
    • Dermatology

    Background:

    • Drug-induced oral lesions are an uncommon but significant adverse effect.
    • Antidepressants, such as doxepin, can manifest various side effects impacting oral health.

    Observation:

    • A 48-year-old woman developed acute glossitis characterized by painful, tender, papular tongue lesions.
    • Symptoms appeared seven days after initiating doxepin and ampicillin therapy.

    Findings:

    • Glossitis resolved with doxepin dosage reduction and discontinuation, and treatment with viscous lidocaine.
    • Recurrence of glossitis upon doxepin reintroduction confirmed the drug as the causative agent.
    • Slow regression of glossitis occurred after subsequent doxepin cessation.

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    Implications:

    • Clinicians should consider drug-induced oral lesions, specifically glossitis, in patients presenting with unexplained oral inflammation and pain.
    • Empirical treatment with topical corticosteroids may be necessary for unresponsive cases of drug-induced glossitis.