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Related Experiment Videos

Is prolactin secreted ectopically?

M E Molitch, S Schwartz, B Mukherji

    The American Journal of Medicine
    |April 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Ectopic prolactin secretion by tumors is rare. This study found only two cancer patients with elevated prolactin levels, likely due to other causes, not ectopic tumor secretion.

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    Area of Science:

    • Endocrinology
    • Oncology
    • Cancer Research

    Background:

    • Ectopic hormone secretion by tumors is a known phenomenon.
    • Prolactin (PRL) secretion by neoplasms is infrequently reported.
    • The clinical significance of potential prolactin hypersecretion in cancer patients is unclear.

    Purpose of the Study:

    • To investigate the incidence of elevated prolactin levels in cancer patients.
    • To determine if cancer itself causes hyperprolactinemia or if other factors are responsible.
    • To assess the evidence for ectopic prolactin secretion by tumors.

    Main Methods:

    • Serum prolactin levels were measured using radioimmunoassay (RIA).
    • A cohort of 215 patients with various malignancies was studied.

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  • Potential confounding factors for hyperprolactinemia were evaluated.

    • Main Results:

    • Elevated prolactin levels (>25 ng/ml) were observed in 15 out of 215 patients.
    • In 12 of these 15 patients, hyperprolactinemia was attributable to medications or prior radiation therapy.
    • Only two patients (1%) had unexplained modest hyperprolactinemia, one with lung cancer and one with breast cancer.

    Conclusions:

    • There is no clear evidence supporting ectopic prolactin secretion by tumors in this study.
    • Hyperprolactinemia in cancer patients is often due to external factors, not the malignancy itself.
    • The rarity of ectopic prolactin secretion contrasts with other hormones, and the reasons remain unknown.