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Demodicosis of ophthalmic concern
American Journal of Ophthalmology
|March 1, 1981
Summary
Human eyelid mites, Demodex folliculorum and Demodex brevis, consume eyelid cells, causing follicular distension and gland damage. Further research is needed to understand their role in ocular disease and develop control strategies.
Area of Science:
- Ophthalmology
- Dermatology
- Parasitology
Background:
- Hair-follicle mites are the only metazoan organisms commonly found in human eyelid pilosebaceous units.
- Two species, Demodex folliculorum and Demodex brevis, inhabit eyelid structures.
Purpose of the Study:
- To investigate the presence and effects of Demodex mites in human eyelid follicles and glands.
- To understand the pathological changes associated with Demodex infestations.
Main Methods:
- Microscopic examination of Demodex mites in various life stages within human eyelid structures.
- Comparative analysis of demodicids from humans and other mammals.
Main Results:
- Demodex folliculorum causes follicular distension, hyperplasia, and keratinization, leading to eyelash cuffing.
- Demodex brevis consumes gland cells, potentially affecting the tear film's lipid layer and causing granulomas or duct blockage.
- Heavy infestations can lead to more extensive pathological changes.
Conclusions:
- Both Demodex folliculorum and Demodex brevis cause significant pathological changes in the human eyelid.
- These mites may act as agents or synergists in causing ocular disease.
- Further studies, including animal models, are required for prevention and control strategies.