Postprandial hormonal inhibition of canine interdigestive gastric motility

Our aim was to determine whether hormones other than gastrin inhibit cyclic interdigestive motility in the proximal stomach. In four conscious dogs with autotransplanted proximal gastric pouches, excluded gastric antrums, and chronic duodenal electrodes, intraluminal pressure of the pouch and electrical activity of the duodenum were monitored before and after gastric instillation of 250 ml of 154 mM NaCl alone or 154 mM NaCl plus 15 kcal/kg of either dextrose, olive oil, casein hydrolysate, or a mixture containing 5 kcal/kg of each of the three nutrients. Dextrose, olive oil, casein, and the mixture abolished the interdigestive cycles in both pouch and duodenum and decreased intrapouch pressure compared with the saline control. The duration of the inhibition was longest with oil (5 h) and shortest with casein (3 h), and the decrease in mean intrapouch pressure was greatest with the mixture (11.8 cmH2O . min) and least with dextrose (9.3 cmH2O . min). Serum gastrin was unchanged by any of the instillates. We concluded that hormones other than gastrin inhibited cyclic interdigestive motility in the proximal stomach.