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[Infusion model for etomidate (author's transl)]

J Schüttler, H Stoeckel, M Wilms

    Der Anaesthesist
    |December 1, 1980
    PubMed
    Summary
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    This study established an etomidate infusion scheme in healthy volunteers, determining the minimal hypnotic plasma concentration and validating a model for therapeutic levels. The findings support predictable etomidate dosing for hypnotic effects.

    Area of Science:

    • Pharmacology and Pharmacokinetics
    • Clinical Anesthesiology

    Context:

    • Etomidate is an anesthetic agent requiring precise dosing for safe and effective use.
    • Understanding etomidate's pharmacokinetic and pharmacodynamic profile is crucial for developing optimal infusion strategies.

    Purpose:

    • To establish an intravenous infusion scheme for etomidate based on pharmacokinetic principles.
    • To determine the minimal plasma concentration of etomidate required for a hypnotic effect.
    • To develop and validate an infusion model for achieving a target therapeutic plasma concentration.

    Summary:

    • Five healthy volunteers received etomidate via an intravenous infusion designed using pharmacokinetic analysis.
    • Plasma etomidate concentrations were measured using gas chromatography, and electroencephalogram (EEG) monitoring correlated drug levels with hypnotic effects.

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  • A model was developed for a therapeutic plasma concentration of 0.5 microgram/ml, involving an initial bolus followed by a maintenance infusion, which showed good correlation between predicted and measured levels.

    • Impact:

    • Identified a minimal hypnotic plasma concentration of approximately 0.3 microgram/ml for etomidate.
    • Validated an infusion model that achieves predictable steady-state plasma levels, facilitating controlled hypnotic effects.
    • Provides a foundation for more precise and individualized etomidate administration in clinical settings.