[Estimation of guanoxabenz in biological fluids (author's transl)]

A molecule sensitive to light, to variations in temperature and pH, guanoxabenz hydrochloride cannot be estimated in biological fluids according to classical technics. The authors propose an analytical method based, during the extraction phase, on the formation of a copper complex extractable in organic medium and in the true phase of measurement, on the transformation, by hydrochloric acid hydrolysis in dichloro-2-6-benzaldehyde, estimated by gas phase chromatography with detection by capture of electrons. The sensitivity and the specificity of the technic authorise its use in pharmacokinetic studies in man.