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Related Experiment Videos

Lisuride in parkinsonism

J D Parkes, M Schachter, C D Marsden

    Annals of Neurology
    |January 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Lisuride, an ergolene derivative, showed immediate, short-term improvements in Parkinsonism symptoms like tremor and rigidity. However, it also induced involuntary movements and, with oral use, cognitive side effects.

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    Area of Science:

    • Neuropharmacology
    • Movement Disorders

    Background:

    • Lisuride is a potent ergolene derivative with endocrine effects comparable to bromocriptine.
    • Parkinsonism encompasses idiopathic, postencephalitic, and drug-induced forms, characterized by motor deficits.
    • Dopaminergic agents are crucial in managing Parkinsonism symptoms.

    Purpose of the Study:

    • To evaluate the efficacy and side effect profile of lisuride in Parkinsonism.
    • To compare lisuride's effects with existing treatments.

    Main Methods:

    • Intravenous administration of lisuride (0.05–0.15 mg) in nine Parkinsonism patients.
    • Oral administration of lisuride (0.8–4.8 mg daily) in the same subjects.
    • Assessment of motor symptoms (tremor, rigidity, akinesia, postural deformity) and adverse effects (chorea, dyskinesia, cognitive changes).

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    Main Results:

    • Intravenous lisuride rapidly improved Parkinsonism motor symptoms for 2–3 hours.
    • Adverse effects included chorea and orofacial dyskinesia with IV administration.
    • Oral lisuride yielded similar symptomatic benefits but also caused reduced awareness and hallucinations.

    Conclusions:

    • Lisuride demonstrates short-term efficacy in improving motor symptoms of Parkinsonism.
    • Potential for inducing involuntary movements and cognitive side effects necessitates careful dosing and monitoring.
    • Lisuride showed limited benefit in a single case of progressive supranuclear palsy.