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[Kanamycin deposition in the peritoneum as affected by dimexide]
Abstract:
The effect of dimexid (dimethylsulfoxide) on kanamycin absorption from the peritoneum was studied on normal albino rats with aseptic peritonitis. Contrary to the present opinion that the rate of various drug absorption into the blood increases under the effect of dimexid, it was shown that intraperitoneal administration of dimexid and kanamycin resulted in deposition of kanamycin in the peritoneum followed by its slow liberation into the blood channel. The concentration of kanamycin in the peritoneum increased 3--8 times under the effect of dimexid, thus prolonging its retention time by 10--13 hours. The depositing effect was more pronounced in the animals with peritonitis.
Insights
Dimethyl sulfoxide (DMSO) enhances kanamycin deposition in the peritoneum, contrary to expectations. This effect prolongs kanamycin retention time, particularly in cases of peritonitis.
Area of Science:
- Pharmacology
- Drug Absorption
- Peritoneal Drug Delivery
Background:
- Dimethyl sulfoxide (DMSO) is often considered to enhance drug absorption.
- The peritoneal absorption kinetics of kanamycin require further investigation.
Purpose of the Study:
- To investigate the effect of DMSO on kanamycin absorption from the peritoneum.
- To evaluate the impact of peritonitis on this interaction.
Main Methods:
- Intraperitoneal administration of DMSO and kanamycin in normal albino rats.
- Induction of aseptic peritonitis in a subset of rats.
- Measurement of kanamycin concentration in peritoneal fluid and blood over time.
Main Results:
- DMSO administration led to significant kanamycin deposition within the peritoneum.
- Kanamycin liberation into the bloodstream was slow and prolonged.
- Peritoneal kanamycin concentrations increased 3-8 fold, extending retention by 10-13 hours.
- The deposition effect was more pronounced in rats with peritonitis.
Conclusions:
- DMSO inhibits rapid kanamycin absorption from the peritoneum, promoting local drug deposition.
- This DMSO-induced peritoneal deposition of kanamycin offers a potential strategy for prolonged local drug therapy.
- The findings challenge the general assumption of DMSO solely enhancing systemic drug absorption.