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Updated: Aug 17, 2026

Electrophysiological Assessment of Murine Atria with High-Resolution Optical Mapping
Published on: February 22, 2018
[Electrocardiographic diagnosis in atrioventricular discordance]
Insights
The first vector of ventricular activation in electrocardiograms (ECGs) is key for diagnosing atrioventricular discordance. Ventricular hypertrophy and repolarization changes on ECGs help identify associated defects and myocardial damage.
Area of Science:
- Cardiology
- Electrophysiology
- Medical Diagnostics
Context:
- Atrioventricular discordance presents complex diagnostic challenges.
- Electrocardiography (ECG) is a crucial tool for cardiac assessment.
- Understanding ECG patterns in discordant atrioventricular connections is vital.
Purpose:
- To analyze ECG characteristics in patients with atrioventricular discordance.
- To identify key ECG markers for diagnosing associated cardiac defects.
- To correlate ECG findings with ventricular anatomy and hypertrophy.
Summary:
- Studied 37 patients with atrioventricular discordance, categorized by situs solitus/inversus and presence of associated defects.
- Identified the first vector of ventricular activation, congruent with atrial activation, as a fundamental diagnostic sign.
- Correlated anatomical right ventricle preponderance with unassociated defects and biventricular hypertrophy with associated defects.
- Utilized AQRS deviation and shortened electrical systole to recognize hypertrophied ventricles and overload.
- Noted that right bundle branch block presence does not correlate with the degree of overload.
- Highlighted primary ventricular repolarization alterations as definitive signs of myocardial damage.
Impact:
- Provides a framework for improved ECG interpretation in atrioventricular discordance.
- Aids in the early diagnosis of associated cardiac anomalies.
- Enhances understanding of ventricular electrophysiology in complex congenital heart disease.
- Offers insights into myocardial status through repolarization analysis.
Abstract:
The ECG of 37 patients with atrioventricular discordance were studied and divided in two main groups: I) Situs solitus and II) situs inversus, either a) without associated defects or b) with associated defects. It was concluded: 1) The first vector of ventricular activation, oriented in the same sense of that of atrial activation is a fundamental diagnostic sign; 2) The preponderance of anatomical right ventricle, leads to the diagnosis of unassociated defects; 3) The recognition of biventricular hypertrophy obliges to the diagnosis of associated defects; 4) The AQRS deviation and the shortening in duration of the local electrical systole help to recognized the hypertrofied ventricle and its overload; 5) The presence of right bundle branch block is not in relation to the degree of overloading; 6) The primary alterations of ventricular repolarization are univocal signs of myocardial damage.
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