Glomerular alterations and proteinuria in the "two-kidney" Goldblatt hypertensive rats

Quantitative and qualitative analyses of urinary proteins were carried out in order to follow permeability changes of the glomeruli during the course of hypertension. Benign and malignant hypertensive cases were separated by the presence of "salt-loosing-syndrome" in the latters. Six hours urinary protein excretion increased significantly from the 2nd postoperative week only in the malignant hypertensive group. Using sodium dodecyl sulfate gel electrophoresis glomerular proteinuria of selective type was commonly found in the benign, moderately unselective type in the malignant hypertensive group respectively. The findings are in accordance with the "double filter" theory of glomerular barrier.