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Updated: Aug 12, 2026

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
Published on: August 18, 2015
Paradoxical effect of high and low dose aspirin in experimental arterial thrombosis
Abstract:
The effect of different dosage regimens of aspirin was investigated in an experimental model of arterial thrombosis. A paradoxical effect with an increase of the arterial thrombus growth could be seen after a first single dose of 100 mg aspirin/kg body weight. When the high dose of aspirin was given repeatedly, a thrombus size minor than under low dose aspirin therapy with 10 mg/kg body weight has been observed. Our experimental thrombosis experiments do not provide sufficient evidence to support antithrombotic therapy with low doses of aspirin.
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