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Effect of ethaverine hydrochloride on cochlear microcirculation

J Prazma, W P Biggers, N D Fischer

    Archives of Otolaryngology (Chicago, Ill. : 1960)
    |April 1, 1981
    PubMed
    Summary

    Ethaverine hydrochloride improved cochlear microcirculation by increasing oxygen levels in the inner ear. This drug enhanced the cochlear microphonic potential, suggesting a benefit for hearing function.

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    Area of Science:

    • Oto-rhino-laryngology
    • Neuroscience
    • Pharmacology

    Background:

    • Cochlear microcirculation is vital for maintaining inner ear function and hearing.
    • Understanding the effects of vasodilators on cochlear physiology is crucial for treating hearing disorders.

    Purpose of the Study:

    • To investigate the impact of ethaverine hydrochloride on cochlear microcirculation.
    • To assess the drug's effects on endocochlear PO2, endocochlear potential (EP), cochlear microphonic (CM) potential, and blood pressure (BP).

    Main Methods:

    • Short-term experiments were conducted on 11 guinea pigs.
    • Measurements included endocochlear PO2 (polarographically), EP, CM potential, and BP.
    • Ethaverine hydrochloride was administered intravenously at doses of 2, 5, and 10 mg/kg.

    Main Results:

    • Doses of 5 and 10 mg/kg significantly elevated endocochlear PO2 for 35-90 minutes.
    • This improvement in cochlear microcirculation correlated with an increase in CM potential.
    • A decrease in EP was observed, likely due to BP decline and direct drug action.

    Conclusions:

    • Ethaverine hydrochloride, at specific doses, enhances cochlear microcirculation and oxygenation.
    • The drug positively influences CM potential, indicating potential benefits for auditory function.
    • Further research is needed to clarify the EP changes and overall therapeutic implications.

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