Binding sites for immune components in human choroid plexus
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Updated: Oct 20, 2026

A Choroid Plexus Epithelial Cell-based Model of the Human Blood-Cerebrospinal Fluid Barrier to Study Bacterial Infection from the Basolateral Side
Published on: May 6, 2016
Abstract:
In immunologically mediated disorders such as systemic lupus erythematosus and experimental serum sickness, immunoglobulin and complement amy be localized in the choroid plexus. This report demonstrates the presence of binding activity for the Fc fragment of IgG in 34 of 36 samples of human choroid plexus. We suggest that the number, distribution, and avidity of these Ig receptors may modulate the occurrence and/or severity of central nervous system symptoms in patients with immunologically mediated systemic diseases.
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