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Binding sites for immune components in human choroid plexus

N S Peress, V A Roxburgh, M C Gelfand

    Arthritis and Rheumatism
    |March 1, 1981
    PubMed
    Summary
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    Researchers found Fc fragment binding activity in human choroid plexus samples. This suggests immunoglobulin receptors in the choroid plexus may influence central nervous system symptoms in autoimmune diseases.

    Area of Science:

    • Neuroimmunology
    • Immunology
    • Pathology

    Background:

    • Immunoglobulin (Ig) and complement can localize in the choroid plexus during immunologically mediated disorders.
    • Systemic lupus erythematosus and experimental serum sickness are examples of such disorders.

    Purpose of the Study:

    • To investigate the presence and activity of Fc fragment binding in human choroid plexus.
    • To explore the potential role of choroid plexus immunoglobulin receptors in central nervous system (CNS) manifestations of autoimmune diseases.

    Main Methods:

    • Analysis of 36 human choroid plexus samples.
    • Demonstration of binding activity for the Fc fragment of immunoglobulin G (IgG).

    Main Results:

    • Fc fragment binding activity was detected in 34 out of 36 (94%) human choroid plexus samples.

    Related Experiment Videos

  • The study identified binding activity for the Fc fragment of IgG.

    • Conclusions:

    • The human choroid plexus possesses binding activity for the Fc fragment of IgG.
    • The quantity, arrangement, and binding strength (avidity) of these Ig receptors may impact the onset and/or intensity of CNS symptoms in patients with systemic autoimmune conditions.