[Nature of fibrinogen B-soluble fibrin monomer complexes precipitable by ethanol and 2-naphthol]

The molecular composition of fibrinogen B, which is formed after addition of 2-naphthol solution in ethanol to pathological blood plasma was studied. The precipitate was found to contain native fibrinogen as well as fibrin monomer possessing fibrinopeptides B. Some proteins similar to the molecular forms of cold-insoluble blood plasma globulin were revealed. The data obtained suggest that fibrinogen B represents soluble complexes of monomeric fibrin with fibrinogen and probably with cold-insoluble globulin. The mechanisms of formation of these complexes and their precipitation by ethanol and 2-naphthol are discussed.