[Interrelationship between the rate of ATP-consuming processes and ATP concentration in intact erythrocytes]

The behaviour of ATP concentrations in intact erythrocytes upon glucose addition to the erythrocyte suspension at a constant rate was studied. At different rates of glucose addition lower than the rate of glucose consumption at normalcy, the corresponding ATP concentrations are established, which are dependent on the rate of glucose influx. The 20% decrease of ATP concentration from the physiological value is observed at a 2-fold decrease of the flux. The results obtained made it possible to establish the dependence of the total rate of ATP consumption on ATP concentration in intact erythrocytes. This dependence is non-linear and shows a dramatic rise in the proximity of the physiological point.