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Updated: Aug 11, 2026

Atomic Force Microscopy Imaging and Force Spectroscopy of Supported Lipid Bilayers
Published on: July 22, 2015
Phase transition behaviour of artificial liposomes composed of phosphatidylcholines acylated with cyclopropane fatty
Abstract:
Phase transitions of liposomes composed of synthetic phoshatidylcholines acylated with the cyclopropane fatty acids, lactobacillic and dihydrosterculic acid, were studied by differential scanning calorimetry. Transition temperatures were approx. 16 degrees C higher than for phosphatidylcholines acylated with the corresponding unsaturated fatty acids, cis-vaccenic and oleic acid. Though our transition temperatures were all several degrees lower than those determined by Silvius and McElhaney ((1979) Chem. Phys. Lipids 25, 125--134), the increase produced by replacement of the double bond with a cyclopropane ring was the same. We propose that this replacement, through its effect on membrane fluidity, may serve to regulate the activity of membrane-associated processes such as transport.
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