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Related Experiment Videos

Malignant diseases among patients with multiple sclerosis

J Palo, J Duchesne, J Wikström

    Journal of Neurology
    |October 7, 1977
    PubMed
    Summary

    Multiple sclerosis (MS) patients in Finland show significantly lower cancer prevalence and mortality rates compared to the general population. This study explores potential links between MS, cancer, and selenium levels.

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    Guidelines for the use of magnetic resonance imaging in diagnosing and monitoring the treatment of multiple sclerosis: recommendations of the Swedish Multiple Sclerosis Association and the Swedish Neuroradiological Society.

    Acta neurologica Scandinavica·2016

    Area of Science:

    • Neurology
    • Oncology
    • Epidemiology

    Background:

    • Multiple sclerosis (MS) is a chronic autoimmune disease affecting the central nervous system.
    • Cancer incidence and mortality rates vary across different populations and disease states.
    • The role of environmental factors and antioxidants, such as selenium, in disease pathogenesis is an area of ongoing research.

    Purpose of the Study:

    • To investigate the frequency of malignant diseases in a cohort of multiple sclerosis patients in Finland.
    • To compare cancer prevalence and mortality rates in MS patients with those of the general Finnish population.
    • To discuss the potential role of selenium in the pathogenesis of both MS and cancer.

    Main Methods:

    • Retrospective cohort study design.
    • Inclusion of 1866 living and 340 deceased multiple sclerosis patients from Finland.
    • Analysis of cancer incidence and mortality data, with comparisons to general population statistics.

    Main Results:

    • A low prevalence (0.64%) and mortality (0.07%) rate of cancer was observed among MS patients.
    • Cancer rates in MS patients were significantly different from the general population.
    • The highest cancer incidence in MS patients occurred between ages 40-49, unlike the general population where rates decline after 50.

    Conclusions:

    • Multiple sclerosis patients exhibit a lower risk of developing cancer compared to the general population.
    • Age-specific cancer incidence patterns differ between MS patients and the general population.
    • The study highlights the need for further research into the potential protective role of selenium in MS and cancer.

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