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Related Experiment Videos

Contact allergy to a stocking dye

M Kousa, M Soini

    Contact Dermatitis
    |December 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    Contact allergy to brown stocking dye was identified in 14 eczema patients. The dye contains nitro-, aminodiazobenzene, and aminoanthraquinone dyes, with common reactions to p-phenylenediamine.

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    Area of Science:

    • Dermatology
    • Allergology
    • Toxicology

    Background:

    • Contact allergy is a significant concern in eczema patients.
    • Textile dyes are potential allergens that can cause contact dermatitis.
    • Identifying specific dye allergens is crucial for patient management.

    Purpose of the Study:

    • To investigate contact allergy to a specific brown stocking dye in eczema patients.
    • To identify the allergenic components within the dye mixture.
    • To determine the prevalence of this allergy in a broader eczema population.

    Main Methods:

    • Patch testing with the brown stocking dye and its suspected components.
    • Clinical assessment of allergic contact dermatitis.
    • Epidemiological analysis of positive test reactions.

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    Main Results:

    • Fourteen eczema patients (13 female, 1 male) showed contact allergy to the brown stocking dye.
    • The dye is a mixture of nitro- and aminodiazobenzene and aminoanthraquinone dyes.
    • Reactions were observed to p-phenylenediamine (11/14), aminoazobenzene (9/12), Disperse Orange 3 (9/12), and Disperse Yellow 3 (4/12).
    • The dye caused positive epicutaneous test reactions in 1.4% (5/362) of consecutive eczema patients.

    Conclusions:

    • Brown stocking dye is a contact allergen in eczema patients.
    • p-Phenylenediamine and other azo dyes are likely responsible for the allergic reactions.
    • This dye represents a relevant allergen in the population of eczema patients.