Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Dobutamine: a hemodynamic evaluation in human septic shock

F Jardin, M Sportiche, M Bazin

    Critical Care Medicine
    |April 1, 1981
    PubMed
    Summary

    Dobutamine infusion (DI) improved hemodynamics in septic shock patients, increasing cardiac index and mean arterial pressure. This treatment is beneficial, especially when high filling pressures indicate fluid overload or cardiac failure.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Primary central nervous system lymphoma of the spinal cord: A LOC network cohort study.

    Revue neurologique·2024
    Same author

    Combining Total Metabolic Tumor Volume With Beta-2-Microglobulin Levels Predicts Outcomes in High-Burden Follicular Lymphoma Patients.

    Hematological oncology·2024
    Same author

    Real-world data for marginal zone lymphoma patients in the French REALYSA cohort: The REALMA study.

    Hematological oncology·2024
    Same author

    Prognostic value of the combination of volume, massiveness and fragmentation parameters measured on baseline FDG pet in high-burden follicular lymphoma.

    Scientific reports·2024
    Same author

    Effect of single-unit transfusion in patients treated for haematological disease including acute leukemia: A multicenter randomized controlled clinical trial.

    Leukemia research·2023
    Same author

    [Primary central nervous system lymphoma following immunotherapy for metastatic melanoma].

    Annales de dermatologie et de venereologie·2019

    Area of Science:

    • Critical Care Medicine
    • Cardiovascular Physiology
    • Pharmacology

    Background:

    • Septic shock presents complex hemodynamic challenges, often involving impaired cardiac function and altered vascular resistance.
    • Understanding the effects of inotropic agents like dobutamine is crucial for optimizing patient management in sepsis.

    Purpose of the Study:

    • To evaluate the hemodynamic effects of dobutamine infusion (DI) in patients diagnosed with septic shock.
    • To assess the impact of DI on key hemodynamic parameters, including cardiac output, blood pressure, and oxygen delivery.

    Main Methods:

    • A study involving 19 patients with septic shock who received dobutamine infusion.
    • Hemodynamic parameters such as cardiac index, stroke index, mean arterial pressure, and mixed venous-arterial oxygen difference (aVDO2) were monitored.

    Related Experiment Videos

  • Effects on pulmonary gas exchange (venous admixture, PaO2) and the influence of mechanical ventilation with positive end-expiratory pressure (PEEP) were assessed.

    • Main Results:

    • Dobutamine infusion significantly improved cardiac index (+36%), stroke index (+15%), and mean arterial pressure (+20%), while decreasing aVDO2 (-27%).
    • A concomitant fall in right and left ventricular filling pressures was observed.
    • In mechanically ventilated patients, DI increased venous admixture (Qs/Qt) (+30%), an effect mitigated by PEEP.

    Conclusions:

    • Dobutamine infusion demonstrates significant hemodynamic benefits in patients with septic shock.
    • DI is particularly useful in managing septic shock complicated by high filling pressures due to fluid overload or cardiac dysfunction.
    • The use of PEEP can counteract potential adverse effects of DI on pulmonary gas exchange in ventilated patients.