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Related Experiment Videos

The "sickle-sign" in bone scintigraphy

H Creutzig, W Dach

    European Journal of Nuclear Medicine
    |March 1, 1981
    PubMed
    Summary

    A bone scan side-effect, the "sickle sign," appears in patients undergoing cytotoxic therapy. A vertex view helps differentiate this harmless finding from cancer spread in the skull.

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    Area of Science:

    • Oncology
    • Radiology
    • Nuclear Medicine

    Background:

    • Cytotoxic chemotherapy can cause a bone scan artifact known as the "sickle sign."
    • This sign presents as diffuse tracer uptake around the calvarium.
    • Distinguishing the sickle sign from malignant findings is crucial for accurate patient management.

    Purpose of the Study:

    • To report the "sickle sign" as a side-effect of cytotoxic treatment on bone scans.
    • To describe a method for differentiating the sickle sign from skull metastases or meningeal carcinosis.
    • To recommend an addition to standard bone scan imaging protocols.

    Main Methods:

    • Review of bone scans in patients undergoing intensive cytotoxic treatment.
    • Analysis of imaging findings, specifically focusing on calvarial activity.
    • Correlation of imaging findings with clinical data and cancer status.
    • Introduction and evaluation of a vertex view in differentiating findings.

    Main Results:

    • The "sickle sign" was identified as a diffuse calvarial activity in patients on cytotoxic therapy.
    • Patients with confirmed skull metastases or meningeal carcinosis exhibiting the sickle sign showed inhomogeneous uptake on vertex views.
    • The vertex view effectively differentiated benign sickle sign from malignant lesions.

    Conclusions:

    • The "sickle sign" is a benign artifact of cytotoxic therapy.
    • A vertex view is essential for differentiating the sickle sign from skull metastases or meningeal carcinosis.
    • Adding a vertex view to standard bone scans is recommended for patients presenting with the sickle sign.

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