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Minocycline diffusion into benign prostatic hyperplasia

T W Hensle, G R Prout, P Griffin

    The Journal of Urology
    |October 1, 1977
    PubMed
    Summary
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    Minocycline effectively concentrates in prostate tissue, showing potential for treating benign prostatic hyperplasia. Higher doses and timely administration enhance drug levels in the prostate.

    Area of Science:

    • Pharmacology
    • Urology
    • Drug Metabolism

    Background:

    • Minocycline, a broad-spectrum tetracycline, is being investigated for chronic prostatitis treatment.
    • Its lipid solubility suggests potential for prostate tissue penetration.

    Purpose of the Study:

    • To evaluate minocycline's concentration in benign prostatic hyperplasia (BPH) tissue.
    • To assess the relationship between dosage, timing, and tissue drug levels.

    Main Methods:

    • Patients undergoing open prostatectomy received preoperative intravenous minocycline.
    • Drug levels were measured in prostate tissue, plasma, fat, muscle, and urine.

    Main Results:

    • Prostate and serum minocycline concentrations were comparable (4.16 vs. 3.01 µg/gm).

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  • Striated muscle and fat tissue showed lower drug levels (2.92 and 0.77 µg/gm).
  • Higher preoperative doses and administration closer to surgery increased serum and prostate levels.

    • Conclusions:

    • Minocycline concentrates effectively in benign prostatic hyperplasia tissue.
    • Rapid diffusion into BPH suggests therapeutic potential.
    • Dosage and timing are critical factors for optimizing prostate drug levels.