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Clinical study on the hypotensive effect of diltiazem hydrochloride
Insights
Diltiazem HCl effectively lowers blood pressure in essential hypertension patients. It also enhances the effect of trichlormethiazide in non-responsive individuals, with minimal side effects.
Area of Science:
- Cardiology
- Pharmacology
Background:
- Essential hypertension is a prevalent cardiovascular condition requiring effective management.
- Diltiazem hydrochloride (HCl) is a calcium channel blocker used for hypertension treatment.
Purpose of the Study:
- To investigate the hypotensive efficacy of Diltiazem HCl in patients with essential hypertension.
- To evaluate the combined effect of Diltiazem HCl and trichlormethiazide in non-responsive patients.
Main Methods:
- Oral administration of Diltiazem HCl at a fixed daily dose of 180 mg.
- Assessment of systolic and diastolic blood pressure changes.
- Evaluation of concurrent Diltiazem HCl and trichlormethiazide therapy.
Main Results:
- Diltiazem HCl alone reduced systolic pressure in 88.9% and diastolic pressure in 66.7% of patients.
- Concurrent use with trichlormethiazide improved blood pressure control in non-responders.
- Reported side effects (gastric fullness, dizziness) were mild and transient.
Conclusions:
- Diltiazem HCl demonstrates significant clinical efficacy as a hypotensive agent.
- Combination therapy with trichlormethiazide expands treatment options for essential hypertension.
- Diltiazem HCl is well-tolerated in the clinical setting.
Abstract:
Diltiazem HCl was administered p.o. at a fixed daily dose level of 180 mg to patients with essential hypertension, and the hypotensive effect of the drug was investigated. The following results were obtained: diltiazem HCl given alone exhibited a hypotensive effect on systolic pressure in 88.9% of the patients and on diastolic pressure in 66.7% of the patients. The concurrent use of diltiazem HCl with trichlormethiazide exerted a hypotensive effect on patients who were nonresponsive to diltiazem HCl alone. As regards side effects, one patient complained of gastric fullness and one of dizziness. However, the symptoms were so mild that further continuation of diltiazem HCl therapy was possible. From the results obtained, it is concluded that diltiazem HCl can effectively be used clinically as a hypotensive drug.