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Giant cell reaction of bone
Italian Journal of Orthopaedics and Traumatology
|August 1, 1980
Summary
Giant cell reaction of bone is an osteolytic lesion affecting hands and feet. These benign lesions heal after surgical excision, with key differential diagnoses including giant cell tumors.
Area of Science:
- Orthopedics
- Pathology
- Skeletal Radiology
Background:
- Giant cell reaction of bone is an osteolytic lesion.
- These lesions commonly affect the small bones of the hands and feet.
- Histologically, they show fibroblastic proliferation with osteoid production and numerous giant cells, but lack atypical cellular features.
Purpose of the Study:
- To present six cases of giant cell reaction of bone.
- To discuss the anatomical and clinical presentation of these lesions.
- To review the differential diagnosis of giant cell-containing bony lesions in the hands and feet.
Main Methods:
- Case series presentation.
- Anatomical and clinical description of six patients.
- Review of differential diagnoses for giant cell lesions in the extremities.
Main Results:
- Six cases of giant cell reaction of bone were identified in the hands and feet.
- The lesions were characterized by benign fibroblastic proliferation and abundant giant cells.
- All cases healed successfully following marginal excision.
Conclusions:
- Giant cell reaction of bone is a benign entity requiring differentiation from other giant cell lesions.
- Marginal excision is an effective treatment for these lesions.
- Key differential diagnoses include giant cell tumors and brown tumors of hyperparathyroidism.