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Total hip replacement in Gaucher's disease
The Journal of Bone and Joint Surgery. American Volume
|April 1, 1981
Insights
Total hip replacement is a viable option for older adults with Gaucher
Area of Science:
- Orthopedic Surgery
- Genetics
- Metabolic Disorders
Background:
- Gaucher's disease, a lysosomal storage disorder, can lead to avascular necrosis and hip complications.
- Adult-onset Gaucher's disease frequently affects the skeletal system, necessitating orthopedic interventions.
Observation:
- Seven total hip replacements were performed in six patients diagnosed with adult Gaucher's disease.
- Patients experienced significant perioperative bleeding, a known complication in Gaucher's disease management.
Findings:
- Three patients required revision surgery due to loosened hip components, particularly younger individuals with severe disease.
- Total hip replacement demonstrated feasibility and potential success in older patients with Gaucher's disease, osteonecrosis, or prior hip surgery failure.
Implications:
- Careful patient selection is crucial, considering age and disease severity for optimal outcomes.
- Further research into managing bleeding complications and improving implant longevity in Gaucher's disease patients is warranted.
Abstract:
We performed seven total hip replacements in six patients with the adult form of Gaucher's disease. Excessive perioperative hemorrhage was a common complication, and three patients have required revision of loosened components. Two of these were young patients with a more severe form of the disease. Total hip replacement is feasible and likely to be successful in the older patient with Gaucher's disease and osteonecrosis or failed prior hip surgery.