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Coagulation studies in Argentine hemorrhagic fever
The Journal of Infectious Diseases
|January 1, 1981
Summary
Argentine hemorrhagic fever (AHF) impacts coagulation factors similarly across disease severity. Factor V activity significantly increased, while fibrinogen levels varied by clinical form, with normalization observed post-day 14.
Area of Science:
- Hematology
- Infectious Diseases
- Epidemiology
Background:
- Argentine hemorrhagic fever (AHF) is a severe viral illness with potential hemostatic complications.
- Understanding coagulation factor dynamics is crucial for managing AHF patients.
Purpose of the Study:
- To investigate coagulation profiles in patients with Argentine hemorrhagic fever.
- To correlate coagulation factor changes with clinical disease severity.
Main Methods:
- Coagulation studies were conducted on 32 AHF patients from day 6 to day 22 post-symptom onset.
- Patients were categorized into mild, moderate, and severe clinical forms.
- Assessed parameters included activated partial thromboplastin time, factors II, V, VII-X, and fibrinogen.
Main Results:
- Activated partial thromboplastin time was prolonged in early stages (day 6-14).
- Factor V activity was significantly enhanced (peak 257.6% on day 10).
- Fibrinogen levels differed by clinical form, increasing in moderate and severe cases by day 12.
Conclusions:
- Coagulation factor profiles in AHF are largely consistent across clinical forms, with notable Factor V enhancement.
- Fibrinogen levels show distinct patterns related to disease severity.
- Coagulation alterations tend to normalize after two weeks, suggesting a dynamic hemostatic response in AHF.