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Related Experiment Videos

A technique for anodally blocking large nerve fibres through chronically implanted electrodes

G S Brindley, M D Craggs

    Journal of Neurology, Neurosurgery, and Psychiatry
    |December 1, 1980
    PubMed
    Summary

    Electrical stimulation can selectively block nerve impulses in spinal roots and peripheral nerves. This technique, using platinum electrodes in a silicone channel, offers a promising method for nerve impulse control.

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    Area of Science:

    • Neuroscience
    • Biomedical Engineering
    • Electrophysiology

    Background:

    • Nerve fiber stimulation and blocking are crucial for understanding neural function and developing therapeutic interventions.
    • Previous methods for nerve impulse control lacked specificity and could cause unwanted side effects.

    Purpose of the Study:

    • To investigate the efficacy and safety of using electrical stimulation via platinum electrodes in a silicone channel to selectively block nerve impulses in spinal roots and peripheral nerves.
    • To determine the optimal parameters for achieving unidirectional nerve block while avoiding anodal break excitation and off-target stimulation.

    Main Methods:

    • Implantation of silicone rubber channels with platinum electrodes around baboon and rhesus monkey spinal roots.
    • Application of electrical pulses to stimulate and block nerve fibers.

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  • Assessment of nerve fiber response, including somatic motor and parasympathetic fibers, over time.

    • Main Results:

    • Selective blocking of somatic motor fibers was achieved, while parasympathetic fibers could be excited but not blocked.
    • Anodal break excitation and stimulation of fibers outside the channel were successfully avoided.
    • Prolonged stimulation with no net direct current proved harmless, and the implant maintained function for at least 26 months.
    • Unidirectional nerve block was demonstrated, and the technique was also effective in blocking peripheral nerves.

    Conclusions:

    • Electrical stimulation through platinum electrodes in a silicone channel provides a safe and effective method for selective nerve impulse blocking.
    • This technique holds potential for applications in neuromodulation and the management of neurological disorders.
    • The ability to achieve unidirectional block and its efficacy in peripheral nerves broadens its potential therapeutic applications.