Cerebrospinal fluid specific proteins in multiinfarct and senile dementia

Cerebrospinal fluid (CSF) from patients suffering from senile dementia (SD) and multiinfarct dementia (MID) was fractionated into CSF-specific and antigenically serum-like proteins, using affinity chromatography with antihuman serum antibodies. The samples were isoelectric focused. Protein patterns were compared to similarly treated CSF from patients suffering from transient ischemic attacks (TIA), or normal volunteers. Characteristic changes were found in the CSF-specific protein pattern from SD patients.