Tumoral calcinosis. A clinical and pathological study of eleven unreported cases in Turkey

Clinicopathological observations of eleven cases of tumoral calcinosis are reported. All of the cases showed characteristic clinical and histopathological features of this unusual condition, but pathological findings did not elucidate all of its etiology and pathogenesis. Two of the patients were related. One of the patients showed skeletal changes characterized by diffuse calcium deposits with widespread soft-tissue calcification. The available data of the present study also led to the suggestion that the disease has a genetic background and that the primary defect may well be in the collagen which undergoes calcification.