Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Lactic acidosis associated with fenformin therapy]

G Ghirlanda, A V Greco, L Altomonte

    Minerva Medica
    |April 7, 1981
    PubMed
    Summary

    Phenformin can cause severe lactic acidosis in diabetic patients, even with normal kidney function. Careful patient selection is crucial for this diabetes medication.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Use of Levosimendan as bridge therapy to surgical correction of post-infarction ventricular septal defect: a case report.

    European review for medical and pharmacological sciences·2021
    Same author

    Editorial - Lies have short legs.

    European review for medical and pharmacological sciences·2020
    Same author

    Levothyroxine absorption in health and disease, and new therapeutic perspectives.

    European review for medical and pharmacological sciences·2014
    Same author

    EuroSCORE as predictor of in-hospital mortality after percutaneous coronary intervention.

    Heart (British Cardiac Society)·2008
    Same author

    Acute myocardial infarction interventional procedures: primary percutaneous coronary intervention versus facilitated percutaneous coronary intervention, rescue angioplasty, rescue excimer laser.

    Minerva cardioangiologica·2007
    Same author

    Safety of granulocyte-colony-stimulating factor in acute myocardial infarction (the Rigenera study).

    Heart (British Cardiac Society)·2006

    Area of Science:

    • Endocrinology
    • Nephrology
    • Pharmacology

    Background:

    • Phenformin is an oral antihyperglycemic agent used in diabetes management.
    • Lactic acidosis is a serious metabolic complication associated with certain medications.

    Observation:

    • Two cases of irreversible lactic acidosis in patients treated with phenformin are presented.
    • Both patients had diabetes mellitus and were receiving phenformin therapy.

    Findings:

    • The first patient presented with a blood creatinine of 3 mg/dL and arterial blood pH of 7.12.
    • The second patient had a blood creatinine of 1.3 mg/dL and arterial blood pH of 7.22.
    • Lactic acidosis occurred despite negative ketostix results and varying serum creatinine levels, including one near-normal value.

    Implications:

    • Phenformin treatment requires careful patient selection and should be reserved for specific indications.
    • Lactic acidosis can occur with phenformin even when serum creatinine levels are not significantly elevated.
    • This highlights the importance of monitoring for lactic acidosis in diabetic patients on phenformin, regardless of renal function markers.

    Related Experiment Videos