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Related Experiment Videos

Dialysability of theophylline

N D Vaziri, C H Barton, R Ness

    Journal of Dialysis
    |January 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Theophylline is highly dialyzable via hemodialysis, clearing at 76 ml/min. This indicates dialysis is effective for treating theophylline intoxication, requiring dose adjustments during treatment.

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    Area of Science:

    • Pharmacokinetics
    • Nephrology
    • Toxicology

    Background:

    • Theophylline is a medication with a narrow therapeutic index.
    • Theophylline overdose can lead to serious toxicity.
    • Understanding drug removal during dialysis is crucial for managing overdosed patients.

    Observation:

    • Theophylline exhibits high dialyzability during hemodialysis.
    • Average dialysis clearance for theophylline was measured at 76 ml/min.

    Findings:

    • Theophylline clearance during hemodialysis reached approximately 63% of urea clearance.
    • This demonstrates significant removal of theophylline via the dialytic process.

    Implications:

    • Patients undergoing hemodialysis require adjusted theophylline dosing.
    • Hemodialysis is an effective method for treating theophylline intoxication.