Serum ceruloplasmin in manganese-treated rats

Rats were exposed to manganese (Mn) (6 mg/kg) daily for 30 days. The content of ceruloplasmin decreased significantly by 19.5% while copper (Cu) content was reduced by 27.8% in the serum of Mn-treated animals. These alterations were associated with a marked increase in the Cu content of liver and brain. The significant decrease in serum Cu and ceruloplasmin may serve as useful parameters for early diagnosis of Mn poisoning.