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Numerical integration simulation programs for the microcomputer

J R Koup, D R Benjamin

    Therapeutic Drug Monitoring
    |January 1, 1980
    PubMed
    Summary
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    This study introduces user-friendly Apple II Plus software for simulating pharmacokinetic models, including linear and Michaelis-Menten types. These programs offer an economical method for visualizing drug behavior in the body.

    Area of Science:

    • Pharmacokinetics and Computational Biology
    • Biomedical Engineering
    • Pharmacometrics

    Background:

    • Pharmacokinetic (PK) modeling is crucial for understanding drug behavior.
    • Simulating PK models aids in dose optimization and therapeutic drug monitoring.
    • Existing simulation tools may be inaccessible or costly for some researchers.

    Purpose of the Study:

    • To describe novel software for simulating linear and Michaelis-Menten pharmacokinetic models.
    • To provide an economical and accessible tool for pharmacokinetic simulations.
    • To facilitate the understanding of drug disposition and kinetics.

    Main Methods:

    • Development of graphic simulation programs for the Apple II Plus microcomputer.
    • Numerical integration of differential equations governing PK models.

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  • Implementation of flexible dosing regimens (oral, IV bolus, infusion) and parameter adjustments.

    • Main Results:

    • The software generates graphic simulations of various pharmacokinetic models.
    • It accommodates multiple, combined dosing routes and schedules.
    • Users can modify doses and PK parameters dynamically during simulations.

    Conclusions:

    • The developed programs offer an economical approach to pharmacokinetic simulation.
    • The software is easily modifiable by users with BASIC programming knowledge.
    • These tools enhance the accessibility of PK modeling for research and education.