Related Experiment Video
Updated: Aug 18, 2026

Assessing Teratogenic Changes in a Zebrafish Model of Fetal Alcohol Exposure
Published on: March 20, 2012
Statistical analysis of teratologic data: problems and advancements
Abstract:
A large scale replicated dose-response teratology study of 2,4,5-T was done in mice. Variability and variance of fecundity parameters and fetotoxicity endpoints are discussed. Another study on rats indicated less variation among teratologic endpoints than in mice. Calculations for the number of animals in strains of mice and rats needed to detect a 5 percent and 10 percent reduction in mean fetal weight or increase in resorptions are given. We concluded that at least 3 replicates with appropriate numbers of pregnant animals are needed to estimate variance for comparison among laboratories or among species. The utility of these calculations for standardizing teratologic studies is discussed.
Related Concept Videos
Regression Toward the Mean
Teratogenicity
Biostatistics: Overview
Discrete variables are...
Toxicity Testing in Animals
Statistical Methods for Analyzing Epidemiological Data

