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Structural and functional differences between the H-2 controlled Ss and Slp proteins

A Ferreira, V Nussenzweig, I Gigli

    The Journal of Experimental Medicine
    |November 1, 1978
    PubMed
    Summary
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    The mouse Ss protein is the fourth component of complement (C4), crucial for hemolytic activity. Its removal significantly decreases C4 activity, unlike the Slp protein.

    Area of Science:

    • Immunology
    • Biochemistry
    • Complement System

    Background:

    • The fourth component of complement (C4) is a key plasma protein in the immune system.
    • The Ss protein and its homolog Slp are structurally similar but functionally distinct in mice.

    Purpose of the Study:

    • To elucidate the functional and structural relationship between mouse Ss protein and complement component 4 (C4).
    • To investigate the role of Ss and Slp proteins in C4 hemolytic activity.

    Main Methods:

    • Functional assays measuring hemolytic activity.
    • Structural analysis of Ss and Slp proteins.
    • Biochemical assays involving C1 enzyme cleavage.

    Main Results:

    • Ss protein removal significantly correlates with decreased C4 hemolytic activity (P < 0.001).

    Related Experiment Videos

  • Plasma/serum Ss levels correlate with C4 activity in Slp-negative mice (P < 0.001).
  • Ss protein (209,000 MW) has three polypeptide chains; C1 cleavage removes a fragment from the alpha-chain. Slp protein shares structural similarities but lacks hemolytic activity and C1 cleavage site.

    • Conclusions:

    • The mouse Ss protein functionally represents the fourth component of complement (C4).
    • Ss protein is essential for C4 hemolytic activity, while Slp protein is not.
    • Structural differences in polypeptide chains and C1 cleavage susceptibility distinguish Ss from Slp.