Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cancer and ageing

L M Franks

    Acta Biologica Academiae Scientiarum Hungaricae
    |January 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    Cancer susceptibility increases with age, but this varies by tissue. Old bladder epithelium transforms more frequently than young, while mesenchymal cells and salivary glands show no age-related difference in transformation frequency.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Neuroblastoma in adults and adolescents: an indolent course with poor survival.

    Cancer·1997
    Same author

    Prostatic cancer: future prospects for diagnosis and screening.

    British journal of urology·1997
    Same author

    An historical perspective of the pathology and treatment.

    Cancer surveys·1995
    Same author

    Vessel-like sprouts from "fibroblasts" in vitro: further evidence for angiogenic hypothesis of wound healing and fibrosis: a comment.

    Cell biology international reports·1988
    Same author

    Bladder cancer cell line cross-contamination: identification using a locus-specific minisatellite probe.

    British journal of cancer·1988
    Same author

    Genetic aspects of tumour metastasis.

    Cancer surveys·1988
    Same journal

    The fiber architecture of the rat median eminence with some accidental observations on the significance of tanycyte processes.

    Acta biologica Academiae Scientiarum Hungaricae·1982
    Same journal

    Serotoninergic afferents in the monkey neostriatum.

    Acta biologica Academiae Scientiarum Hungaricae·1982
    Same journal

    An HRP and 3H-apo-HRP study of the thalamic projections to visual cortical areas in the cat.

    Acta biologica Academiae Scientiarum Hungaricae·1982
    Same journal

    Central nervous regulation of pituitary TSH response induced by thiouracil treatment or by thyroidectomy.

    Acta biologica Academiae Scientiarum Hungaricae·1982
    Same journal

    Postural support of goal-directed movements: the preparation and guidance of voluntary action in man.

    Acta biologica Academiae Scientiarum Hungaricae·1982
    Same journal

    "De novo" formation of synapses by experimentally induced presynaptic dendrites in adult mammalian brain.

    Acta biologica Academiae Scientiarum Hungaricae·1982
    See all related articles

    Area of Science:

    • Gerontology
    • Oncology
    • Cell Biology

    Background:

    • Ageing is a known risk factor for cancer.
    • Understanding the biological mechanisms linking ageing and cancer is crucial for developing preventative strategies.

    Purpose of the Study:

    • To investigate the relationship between ageing and cancer susceptibility using tissue culture and transplantation.
    • To determine if age-associated increases in cancer susceptibility are uniform across different tissue types.

    Main Methods:

    • In vitro transformation experiments on mesenchymal cells, salivary gland epithelium, and bladder epithelium.
    • Tissue transplantation experiments to validate in vitro findings.

    Main Results:

    • Transformation frequency in mesenchymal cells and salivary gland epithelium was not associated with age.

    Related Experiment Videos

  • Old bladder epithelium exhibited a significantly higher transformation frequency compared to young epithelium.
  • Preliminary transplantation experiments corroborated the age-related susceptibility observed in bladder epithelium.

    • Conclusions:

    • Increased susceptibility to cancer with age is tissue-dependent.
    • The bladder is a tissue where ageing demonstrably increases susceptibility to transformation.