Effect of defibrinogenation on wound strength and collagen formation. A study in the rabbit

Wound healing was studied in Arvin-defibrinogenated rabbits by determinations of skin wound strength and by analysis of collagen content in sponge induced granulation tissue. Strength development was found to be delayed in skin wounds as was the accumulation of collagen in granulation tissue. These results indicate that the initial fibrin formation in a wound is of significance for repair.