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Related Experiment Videos

Thyroid hormone-catecholamine interrelationships during exposure to cold

H Storm, C van Hardeveld, A A Kassenaar

    Acta Endocrinologica
    |May 1, 1981
    PubMed
    Summary
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    Cold exposure and noradrenaline infusion increased the T3/T4 ratio in rats, suggesting the sympathetic nervous system influences thyroid hormone metabolism. This impacts thyroxine (T4) conversion to triiodothyronine (T3) under resting conditions.

    Area of Science:

    • Endocrinology
    • Neuroscience
    • Physiology

    Background:

    • Thyroid hormones, including L-triiodothyronine (T3) and L-thyroxine (T4), play crucial roles in regulating metabolism.
    • The sympathetic nervous system (SNS) is known to influence various physiological processes, but its specific role in thyroid hormone metabolism requires further elucidation.

    Purpose of the Study:

    • To investigate the impact of cold exposure and noradrenaline on thyroid hormone levels and metabolism in rats.
    • To explore the relationship between the sympathetic nervous system and thyroxine (T4) metabolism.

    Main Methods:

    • Chronically catheterized rats were used to measure basal plasma levels of adrenalin (A), noradrenalin (NA), T3, and T4.
    • Rats were exposed to cold (4 degrees C) or infused with noradrenaline (NA) at 23 degrees C.

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  • Plasma hormone concentrations and 24-hour urinary iodide excretion were monitored.

    • Main Results:

    • Cold exposure (4 degrees C) for 3, 7, and 14 days significantly increased the plasma T3/T4 ratio and urinary iodide excretion.
    • Venous noradrenaline (NA) plasma concentration increased 6- to 12-fold during cold exposure, while adrenalin (A) remained at basal levels.
    • Noradrenaline (NA) infusion at 23 degrees C also led to a significant increase in the plasma T3/T4 ratio and urinary iodide excretion after 7 days.

    Conclusions:

    • The sympathetic nervous system plays a significant role in regulating thyroid hormone metabolism in rats at resting conditions.
    • Increased noradrenergic activity, induced by cold or direct infusion, enhances the conversion of thyroxine (T4) to triiodothyronine (T3).
    • These findings provide further evidence for the interplay between the SNS and thyroid hormone regulation.