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Updated: Aug 29, 2026

Non-Terminal Blood Sampling Techniques in Guinea Pigs
Published on: October 11, 2014
Pharmacokinetics of terbutaline and theophylline in guinea pigs when administered simultaneously
Abstract:
Simultaneous administration of terbutaline and theophylline to guinea pigs did not cause significant alterations of the pharmacokinetic properties of any of the drugs. Terbutaline sulphate 24 microgram kg-1 and aminophylline 52 mg kg-1 (7.42 . 10(-8) and 2.37 . 10(-4) mol kg-1 respectively) were given by a bolus intravenous injection, producing plasma concentrations in the range 0-15 ng terbutaline sulphate per ml (0-46 nanomol 1(-1)) and 10-85 microgram theophylline per ml (50-429 mumol 1(-1)). Pharmacokinetic analyses of time courses of plasma concentrations of intact drugs and investigations of tissue distribution 1 hour after the administration were performed. The results showed a weak, statistically insignificant trend of the peripheral compartment of the 2-compartment model to sequester a larger fraction of the drugs when these were administered simultaneously.
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