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Updated: Aug 10, 2026

Full-Field Optical Coherence Microscopy for Histology-Like Analysis of Stromal Features in Corneal Grafts
Published on: October 21, 2022
A longitudinal study of corneal astigmatism and total astigmatism
Abstract:
Cross-sectional studies indicate that mean total astigmatism changes with age; varying from as much as 0.62 D with-the-rule during youth to as much as 0.37 D against-the-rule in samples of elderly patients. The present study involves the examination of adult patients who were seen regularly for a period of at least 40 years. Data are analyzed to determine whether the change in corneal astigmatism accounts for the total astigmatic change, and the magnitude of change with age at each of the principal corneal meridians. Results indicate that steepening of the cornea in the horizontal meridian accounts for a major portion of the increase in against-the-rule total astigmatism among older patients.

