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Recurrent pseudomembranous colitis unassociated with prior antibiotic therapy
Archives of Internal Medicine
|April 1, 1981
Summary
Fulminant and recurrent pseudomembranous colitis occurred in an elderly patient without recent antibiotic use. This case suggests Clostridium difficile can cause colitis even without prior antibiotic exposure, necessitating long-term prophylaxis.
Area of Science:
- Gastroenterology
- Infectious Diseases
- Microbiology
Background:
- Pseudomembranous colitis is typically associated with antibiotic use.
- Clostridium difficile is a common cause of antibiotic-associated colitis.
Observation:
- An elderly woman presented with severe, recurrent pseudomembranous colitis.
- She had no antibiotic administration in the preceding year.
- Stool and tissue cultures confirmed Clostridium difficile and its cytotoxin.
Findings:
- Initial treatment with vancomycin hydrochloride was successful.
- A significant relapse occurred after vancomycin discontinuation.
- Low-dose, long-term prophylaxis was required to manage recurrent disease.
Implications:
- Clostridium difficile should be considered in cases of pseudomembranous colitis unrelated to recent antibiotic therapy.
- This case highlights the potential for non-antibiotic-associated C. difficile infections.
- Long-term prophylactic strategies may be necessary for managing recurrent C. difficile colitis.