Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

ESTRIP, a BASIC computer program for obtaining initial polyexponential parameter estimates

R D Brown, J E Manno

    Journal of Pharmaceutical Sciences
    |December 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Temporal indication of marijuana use can be estimated from plasma and urine concentrations of delta9-tetrahydrocannabinol, 11-hydroxy-delta9-tetrahydrocannabinol, and 11-nor-delta9-tetrahydrocannabinol-9-carboxylic acid.

    Journal of analytical toxicology·2001
    Same author

    Single-dose pharmacokinetics of bupropion in adolescents: effects of smoking status and gender.

    Journal of clinical pharmacology·2001
    Same author

    Recommendations for the management of intracranial arteriovenous malformations: a statement for healthcare professionals from a special writing group of the Stroke Council, American Stroke Association.

    Circulation·2001
    Same author

    Immunotoxicity of sodium bromate in female B6C3F1 mice: a 28-day drinking water study.

    Drug and chemical toxicology·2001
    Same author

    The impact of stroke on the cost and level of care in nursing homes: a retrospective population-based study.

    Mayo Clinic proceedings·2001
    Same author

    Evaluation of the immunomodulatory effects of the macrolide antibiotic, clarithromycin, in female B6C3F1 mice: a 28-day oral gavage study.

    Drug and chemical toxicology·2001
    Same journal

    Green, renewable, or low-carbon? A framework for informed solvent selection in pharmaceutical sciences.

    Journal of pharmaceutical sciences·2026
    Same journal

    Theranostic potential of ramucirumab functionalized magnetoliposomes for targeted delivery of sorafenib and MRI.

    Journal of pharmaceutical sciences·2026
    Same journal

    Intranasal mucoadhesive chitosan microspheres of ranolazine: Formulation, design, and pharmacokinetic evaluation.

    Journal of pharmaceutical sciences·2026
    Same journal

    Evolving landscape of drug development for pediatric rare diseases-from successes to strategies for addressing unmet needs.

    Journal of pharmaceutical sciences·2026
    Same journal

    A mathematical framework for predicting tablet weight variability from blend particle size distribution and tooling geometry.

    Journal of pharmaceutical sciences·2026
    Same journal

    Recrystallization can stop nitrosamine formation in ranitidine hydrochloride.

    Journal of pharmaceutical sciences·2026
    See all related articles

    A new BASIC program, ESTRIP, rapidly estimates polyexponential parameters. This program offers advantages for microcomputers and minicomputers, being easily modifiable by users.

    Area of Science:

    • Computational Chemistry
    • Pharmacokinetics
    • Data Analysis

    Background:

    • Exponential stripping is crucial for analyzing complex decay or absorption processes.
    • Accurate parameter estimation is vital for pharmacokinetic modeling and drug development.
    • Existing methods like CSTRIP (FORTRAN IV) are effective but may lack accessibility on modern, smaller computing systems.

    Purpose of the Study:

    • Introduce ESTRIP, a novel BASIC program for exponential stripping.
    • Compare the capabilities of ESTRIP with the established CSTRIP program.
    • Highlight the advantages of ESTRIP for accessibility and user modification on various computer platforms.

    Main Methods:

    • Development of a new BASIC program named ESTRIP.
    • Utilized exponential stripping algorithms for parameter estimation.

    Related Experiment Videos

  • Comparison of ESTRIP's performance and features against CSTRIP.

    • Main Results:

    • ESTRIP enables rapid calculation of initial polyexponential parameter estimates.
    • The program is compatible with microcomputers and minicomputers supporting BASIC.
    • ESTRIP requires relatively small core memory and is easily user-modifiable.

    Conclusions:

    • ESTRIP provides a viable and accessible alternative for polyexponential parameter estimation.
    • The program's design facilitates wider adoption in research settings with limited computational resources.
    • User-friendliness and adaptability are key strengths of the ESTRIP program.