[Structural and functional changes in the liver in chronic recurrent cholecystitis]

Destructive, inflammatory and sclerotic alterations of the hepatic tissue, increased content of lipid inclusions, lysosomes and microbodies in hepatocytes, vesiculation of the endoplasmic reticulum and depletion of ribosomal granules in it were revealed by morphological examinations of liver samples from the gall bladder bed from patients will rarely, frequently and continuously recurring chronic cholecystitis. A relationship between resorption of lipid structures, content of lysosomes and microbodies, and glycogen accumulation in hepatic cells was found. The destructive morphological changes correlated with reduced capacity of the liver to absorb radioactive label, an increase of alanine transaminase level in the blood, and decreased oxidative processes in the mitochondrial fraction of the liver. The results of the study attest to the involvement of the liver in the pathological process in accord with the rate of cholecystitis recurrency.