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Related Experiment Videos

Twins with Alzheimer's disease

R H Cook, S A Schneck, D B Clark

    Archives of Neurology
    |May 1, 1981
    PubMed
    Summary

    Identical twins both developed Alzheimer's disease, but with different ages of onset. This case highlights the complex factors influencing Alzheimer's disease progression and manifestation.

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    Area of Science:

    • Neurology
    • Geriatrics
    • Genetics

    Background:

    • Alzheimer's disease is a progressive neurodegenerative disorder.
    • Twin studies are valuable for understanding the interplay of genetic and environmental factors in disease.

    Observation:

    • A pair of identical twins presented with Alzheimer's disease.
    • One twin experienced symptom onset in her late 60s, while the other had onset at age 83.

    Findings:

    • Both twins exhibited confirmed histopathologic findings consistent with Alzheimer's disease.
    • The age of dementia onset varied significantly between the genetically identical individuals.

    Implications:

    • This case suggests that while genetics play a role, other factors influence Alzheimer's disease onset and progression.
    • Further research is needed to identify factors contributing to the variability in Alzheimer's disease manifestation even in genetically identical individuals.