Direct determination of acetaminophen in plasma by differential pulse voltammetry

A rapid, simple method for the direct determination of acetaminophen in plasma at toxic levels was developed. The method is based on the oxidation of the phenolic moiety of acetaminophen at a carbon paste electrode in a differential pulse voltammetric mode. Linear calibration curves are obtained from 20 to 400 microgram/ml. No sample cleanup is required.