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Related Experiment Videos

Nifedipine and left ventricular function in beta-blocked patients

P I Joshi, J J Dalal, M S Ruttley

    British Heart Journal
    |April 1, 1981
    PubMed
    Summary

    Nifedipine reduced cardiac contractility in patients on beta-blockers, but increased cardiac output due to arterial dilation. This study highlights nifedipine's complex cardiovascular effects.

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    Area of Science:

    • Cardiology
    • Pharmacology

    Background:

    • Beta-blockers are commonly used for cardiovascular conditions.
    • Nifedipine is a calcium channel blocker with vasodilatory properties.

    Purpose of the Study:

    • To investigate the acute effects of nifedipine on left ventricular function and hemodynamics.
    • To assess these effects in patients already receiving beta-blocker therapy.

    Main Methods:

    • Clinical study involving patients on beta-blocker therapy.
    • Measurement of left ventricular function and hemodynamic parameters.
    • Constant heart rate was maintained during the study.

    Main Results:

    • Nifedipine significantly decreased left ventricular peak dP/dt and peak dP/dt x P-1, indicating a negative inotropic effect.

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  • Systemic vascular resistance was significantly reduced, leading to decreased systolic blood pressure.
  • Left ventricular stroke output increased, with non-significant increases in ejection fraction and mean circumferential shortening velocity.
  • No change in left ventricular end-diastolic pressure was observed.

    • Conclusions:

    • Nifedipine increases cardiac output in conjunction with arterial dilation, despite a demonstrable negative inotropic effect.
    • The intrinsic negative inotropic effects of nifedipine may be masked by compensatory sympathetic activity in patients on beta-blockers.