[Dynamics of autoimmune antibodies in the process of transplantable tumor growth in mice]

Effect of the growth of syngeneic tumor transplant on the appearance of antibodies was studied with the use of two mouse strains and four tumors (cervical carcinoma and 3 teratoblastoid tumors). 8--12 days after tumor inoculation the sera from some recipients contained antibodies which reacted with red cells from syngeneic animals as shown by Coomb's indirect test. During tumor growth the frequency of positive reactions decreased. When all the recipients developed palpable tumors, autoantibodies in sera were an extreme rarity. An inverse correlation between the appearance of palpable tumors and the presence of autoantibodies was statistically significant in 3 of 4 experiments. Possible anti-H-2-specificity of these antibodies and application of the autoimmune test for prediction of clinically undetectable tumor relapses are postulated.