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[Antithrombin III: reference values found with a chromogenic substrate (chromozym TH) (author's transl)]

R Hesse, W Tritschler, G Castelfranchi

    Blut
    |April 1, 1981
    PubMed
    Summary

    New reference values for antithrombin III (heparin-cofactor) in plasma were established using a kinetic assay. Plasma antithrombin III levels showed no significant variation with age, sex, smoking status, or common illnesses.

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    Area of Science:

    • Biochemistry
    • Hematology
    • Clinical Chemistry

    Context:

    • Antithrombin III is a crucial plasma protein that regulates coagulation.
    • Accurate reference ranges for antithrombin III are essential for clinical diagnostics and research.
    • Existing assays may have limitations in precision or applicability.

    Purpose:

    • To establish reliable reference values for antithrombin III (AT-III) in a healthy adult population.
    • To validate a new kinetic assay for quantifying plasma AT-III levels.
    • To investigate potential influences of demographic and lifestyle factors on AT-III concentrations.

    Summary:

    • A novel kinetic assay was employed to determine plasma antithrombin III (heparin-cofactor) reference ranges.
    • Established ranges were 10–15 IU/ml at 25°C and 20–29 IU/ml at 37°C for 423 individuals (15–93 years).

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  • No significant variations were observed based on age, sex, pre/postprandial status, smoking, common illnesses, or oral contraceptive use.

    • Impact:

    • Provides updated and robust reference intervals for antithrombin III measurement.
    • The new assay offers a reliable tool for clinical laboratories assessing coagulation disorders.
    • Findings contribute to a better understanding of antithrombin III homeostasis in diverse populations.