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Cefamandole bone diffusion in patients undergoing total hip replacement
Chemotherapy
|January 1, 1981
Summary
Cefamandole effectively penetrates bone, reaching levels above minimum inhibitory concentrations for key bacteria. This antibiotic shows no bone binding, suggesting potential for treating bone infections like osteomyelitis.
Area of Science:
- Pharmacology
- Orthopedic Surgery
- Infectious Diseases
Background:
- Antibiotic penetration into bone is crucial for treating osteomyelitis.
- Understanding cefamandole's bone diffusion is essential for its clinical application.
Purpose of the Study:
- To evaluate cefamandole penetration into human bone tissue.
- To determine if cefamandole binds to bone.
- To compare cefamandole levels with minimum inhibitory concentrations (MICs) of relevant pathogens.
Main Methods:
- Studied cefamandole penetration in 32 normal bone specimens.
- Measured blood contamination using the haemoglobin method.
- Assessed diffusion in both cortical and trabecular bone.
Main Results:
- No cefamandole binding to bone was detected.
- Mean corrected cefamandole levels (5.8 µg/g) exceeded MIC values for Staphylococcus aureus, Haemophilus influenzae, and Enterobacteriaceae.
- Similar diffusion patterns were observed in cortical and trabecular bone.
Conclusions:
- Cefamandole demonstrates adequate penetration into bone tissue.
- The antibiotic's levels exceed MICs for common bone infection pathogens.
- Further research into cefamandole for preoperative prophylaxis and osteomyelitis treatment is warranted.