The effect of indomethacin on the anterior segment of the eye after paracentesis

The prostaglandin-inhibiting effect of Indomethacin (IN) was studied in rabbits, using paracentesis as a stimulus and rise in aqueous protein and fluorescein concentration after intravenous fluorescein injection as parameters. In eye pre-treated with IN eyedrops the rise in fluorescein and protein concentration in the secondary aqueous was less than the control eyes; the rise in the control eyes was less than in the eye of rabbits not treated with IN. There was good correlation between the rise in protein and the rise in fluorescein concentration in the secondary aqueous. The four different 0.5% IN suspensions used showed different PG-inhibiting activity, attributed to the difference in physiochemical composition.